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Semaglutide vs Tirzepatide, same medication class, different receptor targets. Here's what that actually means. Semaglutide targets the GLP-1 receptor, found in the brain, gut, and pancreas. Tirzepatide targets two: GLP-1 and GIP.
The latter fact has greatly precluded any significant pharmacological advancement for the GIP system as a primary treatment strategy for T2DM
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A history of neuropathy, ophthalmopathy, nephropathy and cardiovascular disease at baseline was reported in 11%, 16%, 7% and 0.5% respectively
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