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Combining semaglutide (a GLP-1 receptor agonist) with phentermine (a sympathomimetic) is not FDA-approved as a formal combination, but some providers explore this approach off-label based on differing mechanisms of action

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doi: 10.1186/1478-811X-11-34 94 BartelsALWillemsenATMDoorduinJde VriesEFJDierckxRALeendersKL